Initial sequencing and analysis of the human genome

Lander ES; Linton LM; Birren B; Nusbaum C; Zody MC; Baldwin J; Devon K; Dewar K; Doyle M; FitzHugh W; Funke R; Gage D; Harris K; Heaford A; Howland J; Kann L; Lehoczky J; LeVine R; McEwan P; McKernan K; Meldrim J; Mesirov JP; Miranda C; Morris W; Naylor J; Raymond C; Rosetti M; Santos R; Sheridan A; Sougnez C; Stange-Thomann Y; Stojanovic N; Subramanian A; Wyman D; Rogers J; Sulston J; Ainscough R; Beck S; Bentley D; Burton J; Clee C; Carter N; Coulson A; Deadman R; Deloukas P; Dunham A; Dunham I; Durbin R; French L; Grafham D; Gregory S; Hubbard T; Humphray S; Hunt A; Jones M; Lloyd C; McMurray A; Matthews L; Mercer S; Milne S; Mullikin JC; Mungall A; Plumb R; Ross M; Shownkeen R; Sims S; Waterston RH; Wilson RK; Hillier LW; McPherson JD; Marra MA; Mardis ER; Fulton LA; Chinwalla AT; Pepin KH; Gish WR; Chissoe SL; Wendl MC; Delehaunty KD; Miner TL; Delehaunty A; Kramer JB; Cook LL; Fulton RS; Johnson DL; Minx PJ; Clifton SW; Hawkins T; Branscomb E; Predki P; Richardson P; Wenning S; Slezak T; Doggett N; Cheng JF; Olsen A; Lucas S; Elkin C; Uberbacher E; Frazier M; Gibbs RA; Muzny DM; Scherer SE; Bouck JB; Sodergren EJ; Worley KC; Rives CM; Gorrell JH; Metzker ML; Naylor SL; Kucherlapati RS; Nelson DL; Weinstock GM; Sakaki Y; Fujiyama A; Hattori M; Yada T; Toyoda A; Itoh T; Kawagoe C; Watanabe H; Totoki Y; Taylor T; Weissenbach J; Heilig R; Saurin W; Artiguenave F; Brottier P; Bruls T; Pelletier E; Robert C; Wincker P; Smith DR; Doucette-Stamm L; Rubenfield M; Weinstock K; Lee HM; Dubois J; Rosenthal A; Platzer M; Nyakatura G; Taudien S; Rump A; Yang H; Yu J; Wang J; Huang G; Gu J; Hood L; Rowen L; Madan A; Qin S; Davis RW; Federspiel NA; Abola AP; Proctor MJ; Myers RM; Schmutz J; Dickson M; Grimwood J; Cox DR; Olson MV; Kaul R; Raymond C; Shimizu N; Kawasaki K; Minoshima S; Evans GA; Athanasiou M; Schultz R; Roe BA; Chen F; Pan H; Ramser J; Lehrach H; Reinhardt R; McCombie WR; de la Bastide M; Dedhia N; Blöcker H; Hornischer K; Nordsiek G; Agarwala R; Aravind L; Bailey JA; Bateman A; Batzoglou S; Birney E; Bork P; Brown DG; Burge CB; Cerutti L; Chen HC; Church D; Clamp M; Copley RR; Doerks T; Eddy SR; Eichler EE; Furey TS; Galagan J; Gilbert JG; Harmon C; Hayashizaki Y; Haussler D; Hermjakob H; Hokamp K; Jang W; Johnson LS; Jones TA; Kasif S; Kaspryzk A; Kennedy S; Kent WJ; Kitts P; Koonin EV; Korf I; Kulp D; Lancet D; Lowe TM; McLysaght A; Mikkelsen T; Moran JV; Mulder N; Pollara VJ; Ponting CP; Schuler G; Schultz J; Slater G; Smit AF; Stupka E; Szustakowki J; Thierry-Mieg D; Thierry-Mieg J; Wagner L; Wallis J; Wheeler R; Williams A; Wolf YI; Wolfe KH; Yang SP; Yeh RF; Collins F; Guyer MS; Peterson J; Felsenfeld A; Wetterstrand KA; Patrinos A; Morgan MJ; de Jong P; Catanese JJ; Osoegawa K; Shizuya H; Choi S; Chen YJ; Szustakowki J

Initial sequencing and analysis of the human genome

Lander ES;Linton LM;Birren B;Nusbaum C;Zody MC;Baldwin J;Devon K;Dewar K;Doyle M;FitzHugh W;Funke R;Gage D;Harris K;Heaford A;Howland J;Kann L;Lehoczky J;LeVine R;McEwan P;McKernan K;Meldrim J;Mesirov JP;Miranda C;Morris W;Naylor J;Raymond C;Rosetti M;Santos R;Sheridan A;Sougnez C;Stange-Thomann Y;Stojanovic N;Subramanian A;Wyman D;Rogers J;Sulston J;Ainscough R;Beck S;Bentley D;Burton J;Clee C;Carter N;Coulson A;Deadman R;Deloukas P;Dunham A;Dunham I;Durbin R;French L;Grafham D;Gregory S;Hubbard T;Humphray S;Hunt A;Jones M;Lloyd C;McMurray A;Matthews L;Mercer S;Milne S;Mullikin JC;Mungall A;Plumb R;Ross M;Shownkeen R;Sims S;Waterston RH;Wilson RK;Hillier LW;McPherson JD;Marra MA;Mardis ER;Fulton LA;Chinwalla AT;Pepin KH;Gish WR;Chissoe SL;Wendl MC;Delehaunty KD;Miner TL;Delehaunty A;Kramer JB;Cook LL;Fulton RS;Johnson DL;Minx PJ;Clifton SW;Hawkins T;Branscomb E;Predki P;Richardson P;Wenning S;Slezak T;Doggett N;Cheng JF;Olsen A;Lucas S;Elkin C;Uberbacher E;Frazier M;Gibbs RA;Muzny DM;Scherer SE;Bouck JB;Sodergren EJ;Worley KC;Rives CM;Gorrell JH;Metzker ML;Naylor SL;Kucherlapati RS;Nelson DL;Weinstock GM;Sakaki Y;Fujiyama A;Hattori M;Yada T;Toyoda A;Itoh T;Kawagoe C;Watanabe H;Totoki Y;Taylor T;Weissenbach J;Heilig R;Saurin W;Artiguenave F;Brottier P;Bruls T;Pelletier E;Robert C;Wincker P;Smith DR;Doucette-Stamm L;Rubenfield M;Weinstock K;Lee HM;Dubois J;Rosenthal A;Platzer M;Nyakatura G;Taudien S;Rump A;Yang H;Yu J;Wang J;Huang G;Gu J;Hood L;Rowen L;Madan A;Qin S;Davis RW;Federspiel NA;Abola AP;Proctor MJ;Myers RM;Schmutz J;Dickson M;Grimwood J;Cox DR;Olson MV;Kaul R;Raymond C;Shimizu N;Kawasaki K;Minoshima S;Evans GA;Athanasiou M;Schultz R;Roe BA;Chen F;Pan H;Ramser J;Lehrach H;Reinhardt R;McCombie WR;de la Bastide M;Dedhia N;Blöcker H;Hornischer K;Nordsiek G;Agarwala R;Aravind L;Bailey JA;Bateman A;Batzoglou S;Birney E;Bork P;Brown DG;Burge CB;Cerutti L;Chen HC;Church D;Clamp M;Copley RR;Doerks T;Eddy SR;Eichler EE;Furey TS;Galagan J;Gilbert JG;Harmon C;Hayashizaki Y;Haussler D;Hermjakob H;Hokamp K;Jang W;Johnson LS;Jones TA;Kasif S;Kaspryzk A;Kennedy S;Kent WJ;Kitts P;Koonin EV;Korf I;Kulp D;Lancet D;Lowe TM;McLysaght A;Mikkelsen T;Moran JV;Mulder N;Pollara VJ;Ponting CP;Schuler G;Schultz J;Slater G;Smit AF;Stupka E;Szustakowki J;Thierry-Mieg D;Thierry-Mieg J;Wagner L;Wallis J;Wheeler R;Williams A;Wolf YI;Wolfe KH;Yang SP;Yeh RF;Collins F;Guyer MS;Peterson J;Felsenfeld A;Wetterstrand KA;Patrinos A;Morgan MJ;de Jong P;Catanese JJ;Osoegawa K;Shizuya H;Choi S;Chen YJ;Szustakowki J; ;;

Nature 2001 Vol. 409 pp. -

669

es2001natureinitial

Abstract

The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the …

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medical Evolution databases National Center for Biotechnology Information NCBI NLM MEDLINE Genetics Molecular genetic diseases animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't non-p.h.s. Forecasting conserved sequence P.H.S. Genes Sequence Analysis genome mutation factual chromosome mapping species specificity nucleic acid dna transposable elements repetitive sequences human* proteins / genetics gene duplication pmid:11237011 doi:10.1038/35057062 e s lander l m linton international human genome sequencing consortium cpg islands drug industry gc rich sequence inborn human genome project* private sector proteome public sector rna / genetics dna* / methods

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Initial sequencing and analysis of the human genome

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