Retrieval is one of the stages in case-based reasoning system which find a solution to new problem or case by measuring the similarity between the new case and old cases in the case base. Some of the similarity measurement techniques are involving feature weights that show the importance of the feature in a case. Feature weights can be obtained from a domain expert or by using a feature weighting method either locally or globally. Gradient descent is the feature weighting method which computes global weights for each feature. This research implemented gradient descent to obtain feature weights in case-based reasoning for hepatitis diagnosis and the similarity measurement using weighted Euclidean distance. There are four variations number of case base and test data that used in this research, those are: the first variation using 50% of data as case base and 50% as test data second variation using 60% of data as case base and 40% as test data, third variation using 70% of data as case base and 30% as test data and fourth variation using 80% of data as case base and 20% as test data. For each variation, using 4 kinds of scenario to mark the test data those are in first scenario the test data mark at the end of data, in second scenario the test data mark at the begin of data, in third scenario the test data mark half at the begin and half at the end of data and in the fourth scenario the test data mark in the middle of data. The result of this research showed that the accuracy of the system reaches 100% at scenario 1 in variation 4. Overall of all four variations and four kinds of scenario, the average accuracy of the system was 77.55%, average recall of system was 69.74%, and the average of precision was 78.39%. In addition, the level of accuracy was also influenced by the number of case base and the scenario of case selection for the case base. This is because more cases in the case base, the chances of a system to finding similar cases will be more.