Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study
Abstract
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome comprising familial/genetic HLH (FHL) and secondary HLH. In the HLH-94 study, with an estimated 5-year probability of survival (pSu) of 54% (95% confidence interval, 48%-60%), systemic therapy included etoposid …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
treatment outcome
research support
non-u.s. gov't
female
male
Infant
lymphohistiocytosis
longitudinal studies
hemophagocytic / mortality*
hematopoietic stem cell transplantation / mortality
cyclosporine / therapeutic use
etoposide / therapeutic use*
dexamethasone / therapeutic use*
hemophagocytic / drug therapy*
jan-inge henter
annacarin horne
pmid:28935695
pmc5785801
doi:10.1182/blood-2017-06-788349
elisabet bergsten
antineoplastic combined chemotherapy protocols / therapeutic use
hematopoietic stem cell transplantation / methods
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117304
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