The compound 2-(naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via reactive oxygen species-regulated mitogen-activated protein kinase, protein kinase B, and signal transducer and activator of transcription 3 signaling in human gastric cancer cells
Abstract
Hit, Lead & Candidate Discovery It is reported that 1,4-naphthoquinones and their derivatives have potent antitumor activity in various cancers, although their clinical application is limited by observed side effects. To improve the therapeutic efficacy of naphthoquinones in the treatment of can …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
Cells
Cultured
apoptosis / drug effects*
stomach neoplasms / metabolism
reactive oxygen species
cheng-hao jin
stat3 transcription factor / metabolism
pmid:30222185
doi:10.1002/ddr.21442
jia-ru wang
gui-nan shen
1-naphthylamine / administration & dosage
1-naphthylamine / adverse effects
1-naphthylamine / analogs & derivatives*
1-naphthylamine / chemical synthesis
map kinase signaling system
stomach neoplasms / drug therapy*
stomach neoplasms / pathology
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117244
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