Comparative Genomics of the Eukaryotes
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Comparative Genomics of the Eukaryotes

Gerald M. Rubin;Mark D. Yandell;Jennifer R. Wortman;George L. Gabor;Miklos;Catherine R. Nelson;Iswar K. Hariharan;Mark E. Fortini;Peter W. Li;Rolf Apweiler;Wolfgang Fleischmann;J. Michael Cherry;Steven Henikoff;Marian P. Skupski;Sima Misra;Michael Ashburner;Ewan Birney;Mark S. Boguski;Thomas Brody;Peter Brokstein;Susan E. Celniker;Stephen A. Chervitz;David Coates;Anibal Cravchik;Andrei Gabrielian;Richard F. Galle;William M. Gelbart;Reed A. George;Lawrence S. B. Goldstein;Fangcheng Gong;Ping Guan;Nomi L. Harris;Bruce A. Hay;Roger A. Hoskins;Jiayin Li;Zhenya Li;Richard O. Hynes;S. J. M. Jones;Peter M. Kuehl;Bruno Lemaitre;J. Troy Littleton;Deborah K. Morrison;Chris Mungall;Patrick H. O'Farrell;Oxana K. Pickeral;Chris Shue;Leslie B. Vosshall;Jiong Zhang;Qi Zhao;Xiangqun H. Zheng;Fei Zhong;Wenyan Zhong;Richard Gibbs;J. Craig Venter;Mark D. Adams;Suzanna Lewis;Gerald M. Rubin;Mark D. Yandell;Jennifer R. Wortman;George L. Gabor;Miklos;Catherine R. Nelson;Iswar K. Hariharan;Mark E. Fortini;Peter W. Li;Rolf Apweiler;Wolfgang Fleischmann;J. Michael Cherry;Steven Henikoff;Marian P. Skupski;Sima Misra;Michael Ashburner;Ewan Birney;Mark S. Boguski;Thomas Brody;Peter Brokstein;Susan E. Celniker;Stephen A. Chervitz;David Coates;Anibal Cravchik;Andrei Gabrielian;Richard F. Galle;William M. Gelbart;Reed A. George;Lawrence S. B. Goldstein;Fangcheng Gong;Ping Guan;Nomi L. Harris;Bruce A. Hay;Roger A. Hoskins;Jiayin Li;Zhenya Li;Richard O. Hynes;S. J. M. Jones;Peter M. Kuehl;Bruno Lemaitre;J. Troy Littleton;Deborah K. Morrison;Chris Mungall;Patrick H. O'Farrell;Oxana K. Pickeral;Chris Shue;Leslie B. Vosshall;Jiong Zhang;Qi Zhao;Xiangqun H. Zheng;Fei Zhong;Wenyan Zhong;Richard Gibbs;J. Craig Venter;Mark D. Adams;Suzanna Lewis;
Science 2000 Vol. 287 pp. 2204-2215
198
rubin2000sciencecomparative

Abstract

A comparative analysis of the genomes of Drosophila melanogaster , Caenorhabditis elegans , and Saccharomyces cerevisiae —and the proteins they are predicted to encode—was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.

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DOI:
10.1126/science.287.5461.2204
URL:
https://doi.org/10.1126%2Fscience.287.5461.2204

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ID: 117203
Ref Key: rubin2000sciencecomparative
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