Cryptotanshinone induces reactive oxygen species‑mediated apoptosis in human rheumatoid arthritis fibroblast‑like synoviocytes
Abstract
The present study investigated the mechanisms of apoptosis induced by cryptotanshinone (CT) in human rheumatoid arthritis fibroblast‑like synoviocytes (RA‑FLSs). Cell Counting kit‑8 assay was performed to determine the cytotoxic effects of CT in human RA‑FLSs, including primary RA‑FLS, HFLS‑RA and M …
Keywords
Tumor
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
Proto-Oncogene Proteins c-akt / metabolism
cell line
Fibroblasts / metabolism
arthritis
biomarkers
hu-nan sun
apoptosis / drug effects*
reactive oxygen species / metabolism*
cell survival / drug effects
ying-hua luo
cheng-hao jin
cell proliferation / drug effects
mitochondria / drug effects
pmid:30535477
doi:10.3892/ijmm.2018.4012
rheumatoid / metabolism*
cell cycle / drug effects
mitochondria / metabolism
phenanthrenes / pharmacology*
stat3 transcription factor / metabolism
synoviocytes / drug effects*
synoviocytes / metabolism*
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