Evaluation of a PCR assay for detection of Streptococcus pneumoniae in respiratory and nonrespiratory samples from adults with community-acquired pneumonia
Abstract
Streptococcus pneumoniae is the most common cause of community-acquired pneumonia, but it is undoubtedly underdiagnosed. We used a nested PCR assay (targeting the pneumolysin gene) to detect S. pneumoniae DNA in multiple sample types from 474 adults with community-acquired pneumonia and 183 control …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
adult
Comparative Study
Antigens
DNA
Evaluation Study
Bacterial / analysis
Polymerase Chain Reaction / methods*
pneumonia
streptococcus pneumoniae / genetics
streptococcus pneumoniae / isolation & purification*
streptococcal infections / microbiology
community-acquired infections / microbiology*
pneumococcal / diagnosis
david r murdoch
pmid:12517826
pmc149569
doi:10.1128/jcm.41.1.63-66.2003
trevor p anderson
lance c jennings
pneumococcal / microbiology*
respiratory system / microbiology
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116466
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