Prolactin has a pathogenic role in systemic lupus erythematosus
Abstract
Prolactin, a 23-kDa peptide hormone, is produced by the anterior pituitary gland and extrapituitary sites including the immune cells. Prolactin (PRL) participates in innate and adaptive immune response. PRL stimulates the immune cells by binding to receptor (PRL-R). Binding of PRL to its receptor ac …
Keywords
immunity
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
pregnancy
female
Disease Models
Animal
Hyperprolactinemia / epidemiology
Lupus Erythematosus
Systemic / epidemiology
Antibodies
Receptors
pregnancy complications / epidemiology
pregnancy complications / immunology*
innate
immunocompetence
prolactin / metabolism*
pmid:28130617
doi:10.1007/s12026-016-8891-x
luis j jara
gabriela medina
luis r espinoza
adaptive immunity
antinuclear / blood
bromocriptine / therapeutic use*
dopamine agonists / therapeutic use*
hyperprolactinemia / drug therapy
hyperprolactinemia / immunology*
systemic / drug therapy
systemic / immunology*
lupus nephritis / drug therapy
lupus nephritis / immunology*
pregnancy complications / drug therapy
prolactin / immunology
prolactin / metabolism
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116195
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