Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment
Abstract
Reactivation of herpes simplex virus type 2 (HSV-2) occurs intermittently as perceived clinically and by viral culture. We performed a series of studies to evaluate the frequency and pattern of HSV-2 reactivation using both viral isolation and HSV PCR assay. Daily samples of genital secretions were …
Keywords
Administration
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
u.s. gov't
adult
female
Recurrence
P.H.S.
Clinical Trial
Antibodies
Double-Blind Method
DNA
Viral / analysis
Polymerase Chain Reaction / methods
time factors
controlled clinical trial
pilot projects
l corey
antiviral agents / administration & dosage
antiviral agents / therapeutic use*
oral
cross-over studies
blotting
western
herpesvirus 2
a wald
j zeh
viral / isolation & purification
herpes genitalis / virology*
human / isolation & purification*
acyclovir / administration & dosage
acyclovir / therapeutic use*
serologic tests
human / drug effects
immunocompetence
viral / drug effects
herpes genitalis / drug therapy*
pmid:9062368
pmc507918
doi:10.1172/jci119237
genitalia
female / virology
human / growth & development
sexually transmitted diseases / drug therapy*
sexually transmitted diseases / virology*
virus latency
virus shedding*
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Citation
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115930
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