Adipose tissue expandability and the early origins of PCOS
Abstract
The most prevalent phenotypes of polycystic ovary syndrome (PCOS) are characterized by insulin resistance and androgen excess. The adipose tissue (AT) expandability hypothesis explains the development of insulin resistance in obesity and in cases of AT deficit. In line with this hypothesis, we propo …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
review
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
pregnancy
research support
non-u.s. gov't
female
male
Adipose Tissue / metabolism*
polycystic ovary syndrome / metabolism
polycystic ovary syndrome / etiology*
adipose tissue / pathology*
androgens / physiology
insulin resistance / physiology
pmid:19796964
doi:10.1016/j.tem.2009.06.003
francis de zegher
abel lopez-bermejo
lourdes ibáñez
androgens / metabolism
hyperinsulinism / metabolism
hyperinsulinism / physiopathology
polycystic ovary syndrome / pathology
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115809
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