Comparison of clindamycin, rifampin, tetracycline, metronidazole, and penicillin for efficacy in prevention of experimental gas gangrene due to Clostridium perfringens
Abstract
Gas gangrene caused by Clostridium perfringens is associated with significant mortality and morbidity in spite of penicillin treatment. Although prompt surgical debridement has been established as the primary therapeutic objective, additional studies are needed for determination of the optimal antim …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
non-p.h.s.
female
male
Comparative Study
metronidazole / pharmacology
clindamycin / therapeutic use
anti-bacterial agents / pharmacology
anti-bacterial agents / therapeutic use*
metronidazole / therapeutic use*
tetracycline / therapeutic use
d l stevens
pmid:2879873
doi:10.1093/infdis/155.2.220
k a maier
j e mitten
clindamycin / blood
clindamycin / pharmacology
clostridium perfringens / drug effects
gas gangrene / prevention & control*
metronidazole / blood
penicillin g / blood
penicillin g / pharmacology
penicillin g / therapeutic use
rifampin / blood
rifampin / pharmacology
rifampin / therapeutic use
tetracycline / blood
tetracycline / pharmacology
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115725
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