Resistance to respiratory syncytial virus (RSV) challenge induced by infection with a vaccinia virus recombinant expressing the RSV M2 protein (Vac-M2) is mediated by CD8+ T cells, while that induced by Vac-F or Vac-G recombinants is mediated by antibodies
Abstract
It was previously demonstrated that the vaccinia virus recombinants expressing the respiratory syncytial virus (RSV) F, G, or M2 (also designated as 22K) protein (Vac-F, Vac-G, or Vac-M2, respectively) induced almost complete resistance to RSV challenge in BALB/c mice. In the present study, we sough …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
female
Antibodies
Antigens
cell line
recombination
Inbred BALB C
respiratory syncytial viruses / immunology*
respirovirus infections / immunology
b r murphy
hn protein*
vaccinia virus / genetics
viral envelope proteins
viral proteins*
viral vaccines*
viral / immunology*
m connors
respiratory syncytial viruses / genetics
respirovirus infections / prevention & control
t-lymphocyte subsets / immunology*
viral / genetics
pmid:1731105
pmc240842
doi:10.1128/jvi.66.2.1277-1281.1992
a b kulkarni
cd4 antigens / immunology
cd4-cd8 ratio
cd8 antigens / immunology*
immunization*
lymphocyte depletion
vaccinia virus / immunology*
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114852
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