Novel 1,4‑naphthoquinone derivatives induce reactive oxygen species‑mediated apoptosis in liver cancer cells
Abstract
Derivatives of 1,4‑naphthoquinone have excellent anti‑cancer effects, but their use has been greatly limited due to their serious side effects. To develop compounds with decreased side effects and improved anti‑cancer activity, two novel types of 1,4‑naphthoquinone derivatives, 2,3‑dihydro‑2,3‑epoxy …
Keywords
Tumor
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
gene expression regulation
humans
pubmed abstract
nih
national institutes of health
national library of medicine
reactive oxygen species / metabolism
Apoptosis / drug effects
cell line
liver neoplasms / pathology
cell survival / drug effects
pmid:30592276
pmc6390020
doi:10.3892/mmr.2018.9785
yue wang
ying-hua luo
cheng-hao jin
cell proliferation / drug effects
neoplastic / drug effects
liver neoplasms / drug therapy*
liver neoplasms / genetics
map kinase signaling system / drug effects
mitochondria / drug effects
mitochondria / genetics
naphthoquinones / pharmacology*
stat3 transcription factor / genetics*
p38 mitogen-activated protein kinases / genetics*
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114815
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