Adipose tissue has aberrant morphology and function in PCOS: enlarged adipocytes and low serum adiponectin, but not circulating sex steroids, are strongly associated with insulin resistance
Abstract
In PCOS, adipose tissue has aberrant morphology/function. Increased waist-to-hip ratio indicates abdominal/visceral fat accumulation, but this is not supported by MRI. Enlarged adipocytes and reduced serum adiponectin, together with a large waistline, rather than androgen excess, may be central fact …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
adult
female
body mass index
immunohistochemistry
polycystic ovary syndrome / pathology*
insulin resistance / physiology*
adiponectin / blood*
sex hormone-binding globulin / metabolism
macrophages / pathology
body weight / physiology
cell size
pmid:21084397
doi:10.1210/jc.2010-1290
louise mannerås-holm
henrik leonhardt
malin lönn
adipocytes / pathology*
adipose tissue / pathology*
amyloid / blood
body height / physiology
glycerol / blood
gonadal steroid hormones / blood*
lipoprotein lipase / metabolism
waist circumference
waist-hip ratio
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114492
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