PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance

PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance

Kubota N;Terauchi Y;Miki H;Tamemoto H;Yamauchi T;Komeda K;Satoh S;Nakano R;Ishii C;Sugiyama T;Eto K;Tsubamoto Y;Okuno A;Murakami K;Sekihara H;Hasegawa G;Naito M;Toyoshima Y;Tanaka S;Shiota K;Kitamura T;Fujita T;Ezaki O;Aizawa S;Kadowaki T;;
molecular cell 1999 Vol. 4 pp. -
445
n1999molecularppar

Abstract

Agonist-induced activation of peroxisome proliferator-activated receptor gamma (PPAR gamma) is known to cause adipocyte differentiation and insulin sensitivity. The biological role of PPAR gamma was investigated by gene targeting. Homozygous PPAR gamma-deficient embryos died at 10.5-11.5 dpc due to …

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