Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes
Abstract
Poxviruses encode a multisubunit DNA-dependent RNA polymerase (vRNAP) that carries out viral gene expression in the host cytoplasm. We report cryo-EM structures of core and complete vRNAP enzymes from Vaccinia virus at 2.8 Å resolution. The vRNAP core enzyme resembles eukaryotic RNA polymerase II (P …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
vaccinia virus / genetics
pmid:31835032
doi:10.1016/j.cell.2019.11.024
clemens grimm
hauke s hillen
utz fischer
cryoelectron microscopy
dna-directed rna polymerases / chemistry*
multienzyme complexes / chemistry
multienzyme complexes / ultrastructure
single molecule imaging
transcription factors / chemistry*
vaccinia virus / metabolism
vaccinia virus / ultrastructure*
viral proteins / chemistry*
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