Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the apoptosis signal-regulating kinase (ASK1) signaling cascade

Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the apoptosis signal-regulating kinase (ASK1) signaling cascade

Hu X;Weng Z;Chu CT;Zhang L;Cao G;Gao Y;Signore A;Zhu J;Hastings T;Greenamyre JT;Chen J;;
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Vol. 31 pp. -
724
x2011theperoxiredoxin-2

Abstract

The peroxiredoxin (PRX) family of antioxidant enzymes helps maintain the intracellular reducing milieu and suppresses apoptosis in non-neuronal cells. However, whether PRX can inhibit neuronal apoptosis through specific signaling mechanisms remains poorly understood. Induction of PRX2, the most abun …

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