Androgen signaling pathways driving reproductive and metabolic phenotypes in a PCOS mouse model

Androgen signaling pathways driving reproductive and metabolic phenotypes in a PCOS mouse model

Aflatounian A;Edwards MC;Rodriguez Paris V;Bertoldo MJ;Desai R;Gilchrist RB;Ledger WL;Handelsman DJ;Walters KA;;
the journal of endocrinology 2020 Vol. 245 pp. -
191
a2020theandrogen

Abstract

As the mechanistic basis of polycystic ovary syndrome (PCOS) remains unknown, current management relies on symptomatic treatment. Hyperandrogenism is a major PCOS characteristic and evidence supports it playing a key role in PCOS pathogenesis. Classically, androgens can act directly through the andr …

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