Peroxiredoxin I deficiency increases LPS‑induced lethal shock in mice
Abstract
Peroxiredoxin I (Prx I) plays a role in regulating macrophage proinflammatory cytokine production and gene expression and participates in immune regulation. However, the possible protective role of Prx I in endotoxin‑induced lethal shock is poorly understood. In the present study, western blot analy …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
Liver / pathology
Knockout
liver / drug effects
hu-nan sun
peroxiredoxins / genetics*
shock
pmid:29901182
doi:10.3892/mmr.2018.9170
li feng
ying-hao han
apoptosis / genetics
caspase 3 / genetics
gene expression regulation / genetics
interleukin-10 / blood
lipopolysaccharides / toxicity
macrophages / metabolism
macrophages / pathology
oxidative stress / genetics*
septic / blood
septic / chemically induced
septic / genetics*
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113522
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