Lower respiratory tract respiratory virus infections increase the risk of invasive aspergillosis after a reduced-intensity allogeneic hematopoietic SCT
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Lower respiratory tract respiratory virus infections increase the risk of invasive aspergillosis after a reduced-intensity allogeneic hematopoietic SCT

R Martino;J L Piñana;R Parody;D Valcarcel;A Sureda;S Brunet;J Briones;J Delgado;F Sánchez;N Rabella;J Sierra;R Martino;J L Piñana;R Parody;D Valcarcel;A Sureda;S Brunet;J Briones;J Delgado;F Sánchez;N Rabella;J Sierra;
bone marrow transplantation 2009 Vol. 44 pp. 749-756
278
martino2009bonelower

Abstract

We have analyzed the incidence and risk factors for the occurrence of invasive aspergillosis (IA) among 219 consecutive recipients of an allogeneic hematopoietic SCT after a reduced-intensity conditioning regimen (Allo-RIC). Twenty-seven patients developed an IA at a median of 218 days (range 24–2051) post-Allo-RIC, for a 4-year incidence of 13% (95% confidence interval 4–24%). In multivariate analysis, risk factors for developing IA were steroid therapy for moderate-to-severe graft vs host disease (GVHD) (Hazard Ratio (HR) 2.9, P=0.03), occurrence of a lower respiratory tract infection (LRTI) by a respiratory virus (RV) (HR 4.3, P

Keywords

cell biology public health stem cells internal medicine hematology general medicine/public health

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DOI:
doi:10.1038/bmt.2009.78
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http://dx.doi.org/10.1038/bmt.2009.78

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Ref Key: martino2009bonelower
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