Enhanced pulmonary histopathology is observed in cotton rats immunized with formalin-inactivated respiratory syncytial virus (RSV) or purified F glycoprotein and challenged with RSV 3-6 months after immunization
Abstract
Formalin-inactivated (FI) RSV, purified F glycoprotein in alum, and RSV infection (intranasal) were compared for their immunogenicity, efficacy, and ability to enhance pulmonary histopathology during RSV infection 3 and 6 months following immunization by the intramuscular route. Purified influenza v …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
Comparative Study
Antigens
respiratory syncytial viruses / immunology*
sigmodontinae
time factors
respiratory syncytial viruses / isolation & purification
vaccines
bronchi / pathology
pulmonary alveoli / pathology
enzyme-linked immunosorbent assay
b r murphy
g a prince
hn protein*
viral envelope proteins
viral proteins*
respirovirus infections / immunology*
viral / immunology*
pmid:2251875
doi:10.1016/0264-410x(90)90253-i
a v sotnikov
formaldehyde / pharmacology
inactivated / immunology*
viral vaccines / isolation & purification
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113352
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