Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse
Abstract
Acute myeloid leukemia (AML) with an FLT3 internal tandem duplication (FLT3-ITD) mutation is an aggressive hematologic malignancy with a grave prognosis. To identify the mutational spectrum associated with relapse, whole-exome sequencing was performed on 13 matched diagnosis, relapse, and remission …
Keywords
leukemia
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
female
male
N.I.H.
Extramural
Recurrence
Multicenter Study
Retrospective Studies
myeloid
fms-like tyrosine kinase 3 / genetics*
induction chemotherapy
mutation*
pmid:26438511
pmc4661172
doi:10.1182/blood-2015-05-646240
manoj garg
yasunobu nagata
h phillip koeffler
chromatin / genetics
chromatin / metabolism
dna methylation / genetics
exome*
acute* / drug therapy
acute* / genetics
acute* / mortality
Access
Citation
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113222
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