Protein binding and its significance in antibacterial therapy
Abstract
Serum protein binding of antimicrobials can reduce antimicrobial activity, restrict tissue distribution, and delay drug elimination. Binding percentages of 80 per cent or more have the potential to significantly reduce free drug levels and affect therapeutic efficacy in patients. However, binding-in …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
review
humans
pubmed abstract
nih
national institutes of health
national library of medicine
anti-bacterial agents / therapeutic use
pmid:2671130
w a craig
s c ebert
anti-bacterial agents / pharmacokinetics*
blood proteins / metabolism*
protein binding
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113215
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