Recombinant human respiratory syncytial virus (RSV) monoclonal antibody Fab is effective therapeutically when introduced directly into the lungs of RSV-infected mice
Abstract
Previously, recombinant human respiratory syncytial virus (RSV) monoclonal antibody Fabs were generated by antigen selection from random combinatorial libraries displayed at the tip of filamentous phage. Two such Fabs, which exhibited high binding affinity for RSV F glycoprotein (a major protective …
Keywords
immunization
Administration
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
female
Recurrence
Antibodies
Monoclonal / therapeutic use*
Inbred BALB C
immunotherapy
b r murphy
passive*
respiratory syncytial virus infections / therapy*
viral / administration & dosage
pmid:8108420
pmc43163
doi:10.1073/pnas.91.4.1386
j e crowe
d r burton
intranasal
monoclonal / administration & dosage
viral / therapeutic use*
immunoglobulin fab fragments / administration & dosage
immunoglobulin fab fragments / therapeutic use*
lung diseases / therapy
recombinant proteins / administration & dosage
recombinant proteins / therapeutic use
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113195
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