Antiviral activity of C-alkylated purine nucleosides obtained by cross-coupling with tetraalkyltin reagents
Abstract
2-, 6-, And 8-alkylated (methyl, ethyl, and vinyl) adenosine analogues were synthesized by a palladium-catalyzed cross-coupling of a tetraalkyltin with the halogenated purine nucleosides. The synthesis of the 8-substituted analogues was accomplished using a transient protection procedure. The 6-alky …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
cell line
herpesvirus 1
pmid:8411010
doi:10.1021/jm00072a013
a a van aerschot
p mamos
p a herdewijn
adenosine / analogs & derivatives*
adenosine / chemical synthesis
adenosine / pharmacology
antiviral agents / chemical synthesis*
antiviral agents / pharmacology
hiv-1 / drug effects
hiv-2 / drug effects
human / drug effects
indicators and reagents
organotin compounds*
respiratory syncytial viruses / drug effects
vaccinia virus / drug effects
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113107
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