Selective impairment of hippocampal neurogenesis by chronic alcoholism: protective effects of an antioxidant
Abstract
A major pathogenic mechanism of chronic alcoholism involves oxidative burden to liver and other cell types. We show that adult neurogenesis within the dentate gyrus of the hippocampus is selectively impaired in a rat model of alcoholism, and that it can be completely prevented by the antioxidant ebs …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
Rats
Sprague-Dawley
microscopy
time factors
electron
neurons / drug effects
hippocampus / drug effects*
antioxidants / pharmacology*
pmid:12792022
pmc164688
doi:10.1073/pnas.1230907100
daniel g herrera
almudena g yague
j manuel garcia-verdugo
alcoholism*
antimetabolites / pharmacology
azoles / pharmacology
bromodeoxyuridine / pharmacology
cell division / drug effects
cell survival / drug effects
ethanol / adverse effects*
hippocampus / pathology
neurons / pathology
neuroprotective agents / pharmacology
nitrogen / metabolism
olfactory bulb / drug effects
organoselenium compounds / pharmacology
oxidative stress
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113053
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