A multiband coplanar waveguide (CPW)-fed antenna loaded with metamaterial unit cell for GSM900, WLAN, LTE-A, and 5G Wi-Fi applications is presented in this paper. The proposed metamaterial structure is a combination of various symmetric split-ring resonators (SSRR) and its characteristics were investigated for two major axes directions at (x and y-axis) wave propagation through the material. For x-axis wave propagation, it indicates a wide range of negative refractive index in the frequency span of 2–8.5 GHz. For y-axis wave propagation, it shows more than 2 GHz bandwidth of near-zero refractive index (NZRI) property. Two categories of the proposed metamaterial plane were applied to enhance the bandwidth and gain. The measured reflection coefficient (S11) demonstrated significant bandwidths increase at the upper bands by 4.92–6.49 GHz and 3.251–4.324 GHz, considered as a rise of 71.4% and 168%, respectively, against the proposed antenna without using metamaterial. Besides being high bandwidth achieving, the proposed antenna radiates bi-directionally with 95% as the maximum radiation efficiency. Moreover, the maximum measured gain reaches 6.74 dBi by a 92.57% improvement compared with the antenna without using metamaterial. The simulation and measurement results of the proposed antenna show good agreement.