A novel functional class I lineage in zebrafish (Danio rerio), carp (Cyprinus carpio), and large barbus (Barbus intermedius) showing an unusual conservation of the peptide binding domains
Abstract
Species from all major jawed vertebrate taxa possess linked polymorphic class I and II genes located in an MHC. The bony fish are exceptional with class I and II genes located on different linkage groups. Zebrafish (Danio rerio), common carp (Cyprinus carpio), and barbus (Barbus intermedius) represe …
Keywords
Evolution
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
Molecular
RNA
animals
pubmed abstract
nih
national institutes of health
national library of medicine
models
amino acid sequence
conserved sequence
Comparative Study
DNA
Genes
Base Sequence
Molecular Sequence Data
Phylogeny
Messenger / genetics
messenger / metabolism
complementary / genetics
sequence homology
amino acid
carps / genetics
species specificity
pmid:12165519
doi:10.4049/jimmunol.169.4.1936
corine p kruiswijk
trudi t hermsen
rené j m stet
binding sites / genetics
carps / immunology
cyprinidae / genetics*
cyprinidae / immunology*
mhc class i*
histocompatibility antigens class i / chemistry
histocompatibility antigens class i / genetics
protein conformation
selection
zebrafish / genetics*
zebrafish / immunology*
zebrafish proteins / chemistry
zebrafish proteins / genetics
zebrafish proteins / immunology
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112903
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