Changes in plasma human immunodeficiency virus type 1 RNA associated with herpes simplex virus reactivation and suppression
Abstract
In early trials of antiretroviral therapy, acyclovir was associated with increased survival by an unknown mechanism. The hypothesis that subclinical herpes simplex virus (HSV) reactivation was associated, in vivo, with increased plasma human immunodeficiency virus (HIV) RNA and suppression with a re …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
RNA
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
u.s. gov't
adult
female
male
middle aged
Comparative Study
P.H.S.
Clinical Trial
Viral / analysis
follow-up studies
time factors
antiviral agents / administration & dosage
antiviral agents / therapeutic use*
cd4 lymphocyte count
hiv infections / complications
herpesvirus 2
human / isolation & purification
virus shedding
pmid:12447756
doi:10.1086/345771
timothy schacker
judith zeh
lawrence corey
acyclovir / administration & dosage
acyclovir / therapeutic use*
hiv antibodies / blood
hiv infections / blood
hiv infections / virology*
hiv-1 / isolation & purification*
herpes genitalis / blood
herpes genitalis / complications
herpes genitalis / virology
herpes simplex / blood
herpes simplex / complications
herpes simplex / virology*
simplexvirus / drug effects
simplexvirus / isolation & purification*
simplexvirus / physiology
virus activation / drug effects*
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Citation
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112816
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