leukemia National Center for Biotechnology Information NCBI NLM MEDLINE review RNA humans pubmed abstract nih national institutes of health national library of medicine bacterial proteins / genetics* bacterial proteins / metabolism crispr-associated protein 9 crispr-cas systems* endonucleases / genetics* endonucleases / metabolism gene editing / methods* cystic fibrosis / pathology myeloid acute / pathology pmid:28879854 doi:10.21775/cimb.026.033 muhammad jamal arif ullah khaista rehman anemia sickle cell / genetics sickle cell / pathology sickle cell / therapy clustered regularly interspaced short palindromic repeats* cystic fibrosis / genetics cystic fibrosis / therapy fanconi anemia / genetics fanconi anemia / pathology fanconi anemia / therapy genetic therapy / methods* acute / genetics acute / therapy muscular dystrophy duchenne / genetics duchenne / pathology duchenne / therapy neurodegenerative diseases / genetics neurodegenerative diseases / pathology neurodegenerative diseases / therapy polycythemia vera / genetics polycythemia vera / pathology polycythemia vera / therapy guide / genetics* guide / metabolism