In vitro and in vivo inhibition of ortho- and paramyxovirus infections by a new class of sulfonic acid polymers interacting with virus-cell binding and/or fusion
Abstract
A series of sulfonic acid polymers were shown to be potent and selective inhibitors of respiratory syncytial virus (RSV) and influenza A virus. The compounds inhibit the replication of RSV and influenza A virus in HeLa and MDCK cells, at concentrations of 0.16 and 4.0 micrograms/ml, respectively, an …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
Comparative Study
Inbred BALB C
Receptors
microbial sensitivity tests
respiratory syncytial virus infections / drug therapy*
pmid:8192454
pmc284437
doi:10.1128/aac.38.2.256
s ikeda
j neyts
e de clercq
antiviral agents / pharmacology*
hela cells
influenza a virus / drug effects*
influenza a virus / physiology
influenza b virus / drug effects*
influenza b virus / physiology
influenza
human / drug therapy*
human / prevention & control
scid
polymers / pharmacology
virus / metabolism*
respiratory syncytial virus infections / prevention & control
respiratory syncytial virus
human / drug effects*
sulfonic acids / pharmacology*
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112634
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