UPARANT is an effective antiangiogenic agent in a mouse model of rubeosis iridis
Abstract
Puncture-induced iris neovascularization (rubeosis iridis; RI) in mice is associated with upregulation of extracellular matrix (ECM) degradation and inflammatory factors. The anti-angiogenic and anti-inflammatory efficacy of UPARANT in reducing RI was determined by noninvasive, in vivo iris vascular …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
female
male
Disease Models
Animal
Inbred BALB C
pmid:31243519
pmc6713680
doi:10.1007/s00109-019-01794-w
filippo locri
massimo dal monte
helder andré
angiogenesis inhibitors / pharmacology*
biomarkers / metabolism
inflammation / drug therapy
inflammation / metabolism
iris / drug effects*
iris / metabolism
neovascularization
pathologic / drug therapy*
pathologic / metabolism
vascular endothelial growth factor a / metabolism
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112407
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