Twenty-four-hour area under the concentration-time curve/MIC ratio as a generic predictor of fluoroquinolone antimicrobial effect by using three strains of Pseudomonas aeruginosa and an in vitro pharmacodynamic model
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Twenty-four-hour area under the concentration-time curve/MIC ratio as a generic predictor of fluoroquinolone antimicrobial effect by using three strains of Pseudomonas aeruginosa and an in vitro pharmacodynamic model

Madaras-Kelly KJ;Ostergaard BE;Hovde LB;Rotschafer JC;;
Antimicrobial agents and chemotherapy 1996 Vol. 40 pp. -
263
kj1996antimicrobialtwenty-four-hour

Abstract

Several investigators have suggested that the 24-h area under the concentration-time curve (AUC)/MIC ratio (AUC/MIC24 or AUIC24) can be used to make comparisons of antimicrobial activity between fluoroquinolone antibiotics. Limited data exist regarding the generic predictive ability of AUC/MIC24 for …

Keywords

National Center for Biotechnology Information NCBI NLM MEDLINE pubmed abstract nih national institutes of health national library of medicine models research support non-u.s. gov't regression analysis microbial sensitivity tests pseudomonas aeruginosa / drug effects* biological kinetics ofloxacin / pharmacology anti-infective agents / pharmacology* pmid:8851583 pmc163170 doi:10.1128/aac.40.3.627 k j madaras-kelly b e ostergaard j c rotschafer anti-infective agents / pharmacokinetics ciprofloxacin / pharmacokinetics ciprofloxacin / pharmacology ofloxacin / pharmacokinetics

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http://www.ncbi.nlm.nih.gov/pubmed/8851583

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