A Novel Co-polymer Based on Hydroxypropyl α-Cyclodextrin Conjugated to Low Molecular Weight Polyethylenimine as an in Vitro Gene Delivery Vector
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A Novel Co-polymer Based on Hydroxypropyl α-Cyclodextrin Conjugated to Low Molecular Weight Polyethylenimine as an in Vitro Gene Delivery Vector

Hongliang Huang;Hai Yu;Da Li;Yang Liu;Fenping Shen;Jun Zhou;Qingqing Wang;Guping Tang;Huang, Hongliang;Yu, Hai;Li, Da;Liu, Yang;Shen, Fenping;Zhou, Jun;Wang, Qingqing;Tang, Guping;
International journal of molecular sciences 2008 Vol. 9 pp. 2278-2289
203
huang2008internationala

Abstract

A novel co-polymer based on 2-hydroxypropyl-α-cyclodextrin cross-linked by low molecular weight polyethylenimine was synthesized as a gene delivery vector. The copolymer could bind and condense DNA tightly. It showed lower cytotoxicity than PEI 25kDa in SK-BR-3 cells. Transfection efficiency was increased over 5.5-fold higher than PEI 25 kDa in SK-BR-3 cells in complete serum medium. It is a potential candidate vector for gene therapy.

Keywords

polyethylenimine 2-hydroxypropyl-α-cyclodextrin non-viral gene delivery vector co-polymer

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DOI:
10.3390/ijms9112278
URL:
https://www.mdpi.com/1422-0067/9/11/2278#citedby

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