The "warfarin window" in pregnancy: the importance of half-life
Abstract
Anticoagulation therapy during pregnancy in women with prosthetic cardiac valves is a therapeutic challenge. The use of vitamin K antagonists such as warfarin during pregnancy carries the potential for serious risks to the fetus, especially if these drugs are administered during the first trimester …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
pregnancy
female
gestational age*
pregnancy complications
pmid:21176310
doi:10.1016/s1701-2163(16)34689-8
asnat walfisch
gideon koren
anticoagulants / administration & dosage*
anticoagulants / adverse effects
bone and bones / drug effects
bone and bones / embryology
cartilage / drug effects
cartilage / embryology
fetal diseases / chemically induced*
half-life
heart valve prosthesis*
heparin / administration & dosage
cardiovascular / drug therapy*
warfarin / administration & dosage
warfarin / adverse effects*
warfarin / pharmacokinetics
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111643
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