Nerve Growth Factor Protects Against Alcohol-Induced Neurotoxicity in PC12 Cells via PI3K/Akt/mTOR Pathway
Abstract
In this study, we chose the PC12 cell line as a neuronal model, and our results demonstrate that nerve growth factor can induce autophagy with the neuroprotective effect and regulatory mechanisms of alcohol-induced autophagy in PC12 cells.
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
Ethanol / toxicity*
Rats
dose-response relationship
drug
pmid:27760741
doi:10.1093/alcalc/agw077
liping liu
tiedong sun
jian hu
autophagy / drug effects
autophagy / physiology
nerve growth factor / pharmacology*
neuroprotective agents / pharmacology*
pc12 cells
phosphatidylinositol 3-kinase / metabolism*
phosphoinositide-3 kinase inhibitors
proto-oncogene proteins c-akt / antagonists & inhibitors
proto-oncogene proteins c-akt / metabolism*
signal transduction / drug effects
signal transduction / physiology
tor serine-threonine kinases / antagonists & inhibitors
tor serine-threonine kinases / metabolism*
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Citation
ID:
110998
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110998
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