Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapy
Abstract
The worldwide increase in the prevalence of multi-antibiotic-resistant bacteria has threatened the physician's ability to provide appropriate therapy for infections. The relationship between antimicrobial drug concentration and infecting pathogen population reduction is of primary interest. Using da …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
models
research support
non-u.s. gov't
female
mutation
drug resistance
multiple
time factors
inbred icr
microbial*
pseudomonas infections / drug therapy*
pmid:12865415
pmc164285
doi:10.1172/jci16814
nelson jumbe
arnold louie
george l drusano
anti-bacterial agents / pharmacology*
dose-response relationship
drug
kinetics
theoretical
monte carlo method
ofloxacin / pharmacology
pseudomonas aeruginosa / metabolism
pseudomonas aeruginosa / pathogenicity
quinolones / pharmacology
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110846
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