Amorphous Calcium Carbonate Based-Microparticles for Peptide Pulmonary Delivery
Abstract
Amorphous calcium carbonate (ACC) is known to interact with proteins, for example, in biogenic ACC, to form stable amorphous phases. The control of amorphous/crystalline and inorganic/organic ratios in inhalable calcium carbonate microparticles may enable particle properties to be adapted to suit th …
Keywords
Administration
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
Rats
pmid:26692360
doi:10.1021/acsami.5b09023
frederic tewes
oliviero l gobbo
anne marie healy
inhalation
aerosols / chemistry
aerosols / therapeutic use
calcitonin / administration & dosage
calcitonin / chemistry
calcium carbonate / administration & dosage
calcium carbonate / chemistry*
lung diseases / drug therapy*
lung diseases / pathology
nanoparticles / administration & dosage
nanoparticles / chemistry*
particle size
peptides / administration & dosage
peptides / chemistry*
alpha 1-antitrypsin / administration & dosage
alpha 1-antitrypsin / chemistry
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110337
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