Driver Fusions and Their Implications in the Development and Treatment of Human Cancers
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Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

Gao Q;Liang WW;Foltz SM;Mutharasu G;Jayasinghe RG;Cao S;Liao WW;Reynolds SM;Wyczalkowski MA;Yao L;Yu L;Sun SQ; ; ;Chen K;Lazar AJ;Fields RC;Wendl MC;Van Tine BA;Vij R;Chen F;Nykter M;Shmulevich I;Ding L;;
Cell reports 2018 Vol. 23 pp. -
456
q2018celldriver

Abstract

Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation rate. Integration of gene expression, copy num …

Keywords

Tumor National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support N.I.H. Extramural pmid:29617662 pmc5916809 doi:10.1016/j.celrep.2018.03.050 qingsong gao wen-wei liang li ding antineoplastic agents / pharmacology* antineoplastic agents / therapeutic use carcinogenesis / drug effects carcinogenesis / genetics* carcinogenesis / metabolism cell line molecular targeted therapy / methods neoplasms / drug therapy neoplasms / genetics* neoplasms / pathology oncogene fusion* oncogene proteins fusion / chemistry fusion / genetics fusion / metabolism

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