When a decision must be made about inflammatory versus malignant diseases of the pancreas, close interdisciplinary cooperation is required, especially with the radiologist. The tash of improving contemporary strategies in the therapy of pancreatic diseases is a challenge for internists, radiologists and surgeons alike. The first encouraging results of this collaboration have now emerged. Nonetheless, when considering the current hospital settings, it is mandatory to continue the ongoing dialogue to optimize the procedures for diagnosing prancreas disease according to the motto less is more and adjust them according to the clinical requirements.