A new series of -triazine hydrazone derivatives was prepared based on the reaction of 6-hydrazino-2,4-disubstituted--triazine with -substituted benzaldehyde derivatives using a straightforward synthetic pathway. The antiproliferative activity of all synthesized compounds was evaluated against two human cancer cell lines; breast cancer MCF-7 and colon carcinoma HCT-116 using MTT assay. Among all, 11 compounds have shown strong to moderate antiproliferative activity with IC values in the range 1.01-18.20 µM in MCF-7 and 0.97-19.51 µM in HCT-116. The best results were obtained with 4,4'-(6-(2-(pyridin-2-ylmethylene)hydrazinyl)-1,3,5-triazine-2,4-diyl) dimorpholine (IC = 1.0 µM and 0.98 µM in MCF-7 and HCT-116 cell lines, respectively). The substituents on the triazine core as well as the substituent at the benzylidene moiety have a great effect on the antiproliferative activity. Whereas compounds containing dimorpholino--triazine derivatives showed more potent antiproliferative in MCF-7 compared to their analogs (compounds containing two-piperidine rings), compounds containing one piperidine and one morpholine ring showed better IC values in the range 10.4-22.2 µM. On the other hand, compounds containing two-piperidine rings showed more potent antiproliferative in HCT-116 (IC values in the range 8.8-19.5 µM) than their analogs and .