Although brain, one of the most complex organs in the mammalian body, has been subjected to many studies from physiological and pathological points of view, there remain significant gaps in the available knowledge regarding its biomechanics. This article reviews the research trends in brain biomechanics with a focus on injury. We used published scientific articles indexed by Web of Science database over the past 40 years and tried to address the gaps that still exist in this field. We analyzed the data using VOSviewer, which is a software tool designed for scientometric studies. The results of this study showed that the response of brain tissue to external forces has been one of the significant research topics among biomechanicians. These studies have addressed the effects of mechanical forces on the brain and mechanisms of traumatic brain injury, as well as characterized changes in tissue behavior under trauma and other neurological diseases to provide new diagnostic and monitoring methods. In this study, some challenges in the field of brain injury biomechanics have been identified and new directions toward understanding the gaps in this field are suggested.