A pneumonia outbreak associated with a new coronavirus of probable bat origin.
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A pneumonia outbreak associated with a new coronavirus of probable bat origin.

Zhou, Peng;Yang, Xing-Lou;Wang, Xian-Guang;Hu, Ben;Zhang, Lei;Zhang, Wei;Si, Hao-Rui;Zhu, Yan;Li, Bei;Huang, Chao-Lin;Chen, Hui-Dong;Chen, Jing;Luo, Yun;Guo, Hua;Jiang, Ren-Di;Liu, Mei-Qin;Chen, Ying;Shen, Xu-Rui;Wang, Xi;Zheng, Xiao-Shuang;Zhao, Kai;Chen, Quan-Jiao;Deng, Fei;Liu, Lin-Lin;Yan, Bing;Zhan, Fa-Xian;Wang, Yan-Yi;Xiao, Geng-Fu;Shi, Zheng-Li;
Nature 2020 Vol. 579 pp. 270-273
314
zhou2020anature

Abstract

Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor-angiotensin converting enzyme II (ACE2)-as SARS-CoV.

Keywords

Epidemiology infection drought coronavirus risk outbreak bat epidemic sars-cov exposure wildlife sars covid-19 2019-ncov ace2 cov severe acute respiratory syndrome angiotensin-converting enzyme 2 wuhan pneumonia green light host red light

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DOI:
10.1038/s41586-020-2012-7

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