Aim of the paper is to quantify effects of socioeconomic factors on Alzheimer’s Disease Mortality in the Slovak Republic. We applied potential gains in life expectancy (PGLE) method to measure the impact of elimination of Alzheimer’s disease on life expectance in Slovak regions. PGLE is based on life table adjustment according to elimination of mortality caused by specific diagnosis. Our dataset consists of all deceased from Slovak Republic from 2001 to 2015. We analyse the impact of unemployment rate, GDP per capita, average wage, and education on life expectance in Slovak regions. To estimate that impact, ordinary least squares (OLS) is applied. According to our model, gross domestic product, average wage, and education influence mortality caused by Alzheimer’s disease.