In this research we synthesized and tested for antimicrobial activity 21 nitrofurazone analogues. The compounds we obtained were identified on the basis of H NMR and C NMR spectroscopy. The screening of antimicrobial properties of synthesized compounds revealed a wide spectrum of antimicrobial activity. Compounds , , -, and - showed very high bactericidal effect towards spp. ATTC and spp. ATTC (MIC = 0.002-7.81 µg/ml and MBC = 0.002-31.25 µg/ml). The levels of activity of several compounds were far better than those of nitrofurantoin, ciprofloxacin or cefuroxime.