Reaction of 1-adamantyl carbohydrazide () with various substituted benzaldehydes and acetophenones yielded the corresponding hydrazide-hydrazones with a 1-adamantane carbonyl moiety. The new synthesized compounds were tested for activities against some Gram-negative and Gram-positive bacteria, and the fungus . Compounds , , , and displayed potential antibacterial activity against tested Gram-positive bacteria and , while compounds and possessed cytotoxicity against tested human cancer cell lines.