To assess the prevalence of depression among university students in Pakistan.The descriptive cross-sectional study was conducted from October 1, 2017, to February25, 2018, at Agriculture University, Faisalabad, Gomal University, Dera Ismail Khan, PirMehr Ali Shah Arid Agriculture University, Rawalpindi, University of Peshawar and Qurtuba University, Dera Ismail Khan, Pakistan. Data was collected using a pre-tested, structured questionnaire, and was analysed using SPSS 19.Of the 1159 subjects, 367(31.6%) were males and 792(68.3%) were females. The overall age range was 19-45 years. Of all the subjects, 986(85%) had some degree of depression, while 173(15%) were normal. Depression in females was significantly higher than males (p<0.05). Depression also had a significant association with academic grades (p<0.001).Depression was found to be common among university students in Pakistani.