Employee engagement is the key factor in any success in the organization’s growth, quality, and good performance. This study conducted to shed insights on the effect that job resources, job demands, and uncertain working environments have an impact on the banking industry in South Sudan. The study focused on addressing the following objectives: To find out the relationships between job demands, job resources and employee engagement in the context of South Sudan; to explore the role of uncertain working environment on employee work engagement. We received the final responses from a sample of 160 employees. The quantitative research technique was used by analyzing our data via SPSS software. The study found that job resources positively affect employee work engagement, job demands had a negative significant influence on the relationship between job resources and employee work engagement. The uncertain work environment also negatively moderates job resources and work engagement relationships.