Advances in drug delivery have made considerable contribution to the clinical therapies for a large range of diseases; however, there still are critical gaps between outcomes in small animal models and actual human products. Over the half-century experience of the drug delivery field, few breakthrough discoveries in drug delivery technologies significantly changed scientific view and promote scientific progress. Many of which were not results or inventions of brand-new and unknown technologies or mass information of long-term studies, but mostly outcomes of a new way of thinking, a novel use of the then available options. It was more like that the needs for better solutions were already existed, yet a brilliant mind was needed to exploit them. art can be a tool to improve problem-solving skills as well as increasing creativity which in turn adds on to the mentioned skills since evidences link creativity with the ability to find innovative solutions to problems. This role of art as a driving force of problem solving has been employed in design of many technologies from the well-honed skills of Leonardo Da Vinci to Samuel Morse, and Alfred L.Copley. Here in, we discuss why art and drug delivery system design should be united.