BACKGROUND: Despite that physiotherapists (PTs) are supposed to have adequate knowledge of musculoskeletal disorders and the different prevention strategies, they are at high risk of developing work-related musculoskeletal disorders (WRMDs). AIM: This study aimed to investigate the prevalence, profile, predictors, and response to WRMDs among Egyptian PTs. METHODS: A self-administrated questionnaire was distributed either manually or via e-mail to 564 PTs with at least two years of working experience. Questions elicited information about the personal and occupational history of the respondents in addition to the experience of WRMDs in the past two years. RESULTS: Four hundred and fourteen respondents (82.6%) reported WRMDs within the last two years, with the lower back as the most common area affected (68.8%). More than half the PTs (54.8%) who sustained a WRMD reported that their injury took place in a private setting. Significant predictors for WRMDs were age (AOR = 0.78; 95% CI = 0.66, 0.91) and number of years of experience in physiotherapy practice (AOR = 1.26; 95% CI = 1.07, 1.49). In response to the injury, about 73.9% of the respondents stated that they did not officially report their injury and 55.8% of them reported losing a half day or more from their work. CONCLUSION: The prevalence of WRMDs among Egyptian physiotherapists is high. Despite socioeconomic and cultural differences between Egypt and other countries, our study findings were consistent with the published reports. Further studies are needed to explore the cultural and psychosocial risk factors of WRMDs.